EXOSOMES DERIVED FROM HUMAN ADIPOSE MESENCHYMAL STEM CELLS AMELIORATE HEPATIC FIBROSIS BY INHIBITING PI3K/AKT/MTOR PATHWAY AND REMODELING CHOLINE METABOLISM

Abstract Liver fibrosis is a chronic liver disease with the presence of progressive wound healing response caused by liver injury.Currently, there are no approved therapies for liver fibrosis.Exosomes derived from Chromium human adipose mesenchymal stem cells (hADMSCs-Exo) have displayed a prominent therapeutic effect on liver diseases.However, few

ABSTRACT Decision support for nutrient application remains an enigma if based on soil nutrient analysis.If the crop could be used as an auxiliary indicator, the plant nutrient status during different growth stages could complement the soil test, improving the fertilizer recommendation.Nutrient absorption and partitioning in the plant are here studi

Neurotrophins CLOCKS (NTs) represent a group of growth factors with pleiotropic activities at the central nervous system level.The prototype of these molecules is represented by the nerve growth factor (NGF), but other factors with similar functions have been identified, including the brain derived-growth factor (BDNF), the neurotrophin 3 (NT-3), a

Background: Abetalipoproteinemia is a rare disorder of fat absorption, characterized by vitamin deficiency, acanthocytosis, and neurologic symptoms including ataxia and tremor.Case Report: A Tweed Blazers 41-year-old male with abetalipoproteinemia is presented.He underwent staged bilateral thalamic deep brain stimulation (DBS) for the tre